• Short-Term Risks: Drowsiness, slurred speech, blurred vision, nausea, vomiting, high blood pressure, rapid heart rate, disorientation, and panic attacks. High doses can cause a loss of motor control, unconsciousness, or a severe disorienting state known as a “K-hole”.
• Long-Term Risks:

• • • Bladder and Urinary Damage: Persistent use can cause severe bladder shrinkage, pain, and loss of bladder control (often called ketamine bladder syndrome).
    • Abdominal Pain: Intense, recurring stomach cramps (often called “K cramps”).
    • Cognitive and Mental Health Issues: Memory loss, poor concentration, depression, anxiety, and psychological addiction. 

• Safety Warning: Mixing ketamine with alcohol, opioids, or other central nervous system depressants dramatically increases the risk of fatal overdose or respiratory failure.

Ketamine Powder (Ketamine Hydrochloride) — High-Purity Analytical Standard

Brand Name: Aura Biochemicals

Chemical Name: $(\pm)\text{-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one hydrochloride}$

CAS Registry Number: 1867-66-9

Chemical Formula: $\text{C}_{13}\text{H}_{16}\text{ClNO} \cdot \text{HCl}$

Molar Mass: $274.19 \text{ g/mol}$

Assay (Purity): $\ge 99.5\%$ (HPLC / Mass Spectrometry Verified)

Physical Form: Crystalline Solid / Ultra-Pure Powder

Grade: Analytical Reference Standard / Laboratory Grade

Technical & Physical Specifications

1. Product Overview & Research Grade Applications

Ketamine Powder (supplied as Ketamine Hydrochloride) is an arylcyclohexylamine derivative widely used across neuropharmacology, biochemical research, and forensic standard modeling. Engineered under strict ISO 17025 and ISO 9001 quality guidelines, Aura Biochemicals supplies ultra-pure Ketamine powder specifically prepared for quantitative assay development, receptor binding studies, and institutional research.

           [ Secondary Mechanism Pathway ]
 Ketamine Powder (CAS 1867-66-9) ──> Non-competitive NMDA Antagonism
                                                │
                                                ▼
  mTORC1 Pathway Activation <── BDNF Burst <── AMPA Depolarization

Key Preclinical Research Applications

• Quantitative Assay Calibration: Serves as a primary reference standard for HPLC, GC-MS, and LC-MS/MS instrument calibration and method validation.

• Glutamatergic Signaling Analysis: Enables accurate mapping of N-methyl-D-aspartate (NMDA) receptor inhibition at the phencyclidine (PCP) intrachannel binding site.

• Synaptogenesis & Antidepressant Pathways: Used in animal models to study rapid-acting neuroplastic modifications, dendritic spine density increases, and brain-derived neurotrophic factor (BDNF) activation.

• Analgesia & Nociception Preclinical Models: Essential for studying central sensitization, chronic pain modulation, and opioid-sparing co-therapies.

2. Chemical Structure & Identification

Ketamine Hydrochloride consists of an equal mixture of $(S)\text{-ketamine}$ (esketamine) and $(R)\text{-ketamine}$ (arketamine) enantiomers.

          O
          ║
      ┌───C───┐
      │       │     
  Cl─►│       │───NH─CH3  • HCl
      └───┬───┘
          │
        (C6H4)

• IUPAC Name: 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one hydrochloride

• Canonical SMILES: CNC1(CCCCC1=O)C2=CC=CC=C2Cl.Cl

• InChI Key: InChIKey=VCMGMSHEPQENPE-UHFFFAOYSA-N

• Exact Monoisotopic Mass: $237.092 \text{ g/mol}$ (Free Base), $274.19 \text{ g/mol}$ (HCl Salt)

3. High-Intent Long-Tail Keywords for Procurement

To ensure rapid indexing and rank top-of-funnel queries for institutional procurement, Aura Biochemicals optimizes for high-conversion search strings:

• Buy high purity Ketamine powder for research laboratories

• Ketamine Hydrochloride CAS 1867-66-9 analytical standard supplier

• Bulk Ketamine powder 99.5% HPLC certified reference material

• Institutional supplier of Ketamine HCl powder with CoA

• ISO 17025 compliant Ketamine reference standard price quote

4. Buy Ketamine Powder Online/Quality Control & Documentation Standards

Every batch of Ketamine Powder dispatched by Aura Biochemicals includes an exhaustive verification dossier:

1. HPLC Purity Trace: Confirms analyte single-peak retention without uncharacterized degradation products.

2. FT-IR & Proton NMR Spectra: Confirms structural signature match against certified standard libraries.

3. Mass Spectrometry (LC-MS): Validates the parent ion mass ($m/z = 238.1$ base ion).

4. Heavy Metal & Solvent Residue Report: Ensures compliance with ICH Q3C residual solvent thresholds.

5. Bulk Order Tiers & Institutional Packaging

6. Safety, Storage & Regulatory Compliance

Institutional Notice: Ketamine Hydrochloride is a controlled substance in multiple global jurisdictions. Products are shipped strictly to verified laboratories holding active research credentials, DEA registrations, or institutional End-User Declarations (EUD).

Handling Guidelines

• Personal Protection: Wear eye protection, nitrile gloves, and work inside a certified chemical fume hood.

• Storage Condition: Keep container sealed under inert atmosphere in a cool, dry area away from direct sunlight ($15^\circ\text{C} – 25^\circ\text{C}$).

7. Ordering Procedure

Frequently Asked Questions (FAQ)

1. What is the purity level of Aura Biochemicals’ Ketamine Powder?

Our Ketamine Powder is guaranteed at $\ge 99.5\%$ purity as determined by High-Performance Liquid Chromatography (HPLC).

2. Is this material suitable for in vitro binding assays?

Yes, this analytical reference standard is designed for in vitro receptor binding assays, chromatographic calibration, and preclinical neuropharmacology research.

3. How do I request a SDS and Certificate of Analysis (CoA)?

Certificates of Analysis accompany every shipment. Digital SDS and CoA copies can be requested directly via sales@aurabiochemicals.com